Autism & Gut Bacteria

Children with autism appear to have a characteristic chemical signature in their urine which might form the basis of an early diagnostic test for the condition.

The finding also adds weight the hypothesis that substances released by gut bacteria are contributing to the onset of the condition.

Autism has previously been linked to metabolic abnormalities and gastrointestinal problems such as gut pain and diarrhoea. Several studies have also hinted at changes in gut bacteria in the faeces of children with autism.

To investigate whether signs of these metabolic changes might be detectable in children’s urine, Jeremy Nicholson and colleagues at Imperial College London investigated 39 children with autism, 28 of their non-autistic siblings and 34 unrelated children.

Chemical fingerprint

Using nuclear magnetic resonance (NMR) spectroscopy to analyse the children’s urine, they found that each of these groups had a distinct chemical fingerprint, with clear and significant differences between children with autism and unrelated controls.

“The signature that comes up is related to gut bacteria,” says Nicholson. It is not yet clear whether the bacteria’s metabolic products contribute to the development of autism, but it is a possibility worth investigating, he adds. A large proportion of autistic children have severe gastrointestinal problems that tend to appear at about the same time as the behavioural symptoms.

“It adds another link to the gut bacterial involvement in the onset of disorder,” says Glenn Gibson of the University of Reading, UK, who has previously identified abnormally high levels of clostridium bacteria in children with autism.

One possibility is that the gut bacteria in children with autism are producing toxins that might interfere with brain development. One of the compounds identified in the urine of autistic children was N-methyl-nicotinamide (NMND), which has also been implicated in Parkinson’s disease.

Inducing autism

Meanwhile, Derrick MacFabe of the University of Western Ontario in London, Canada, and his colleagues have found that short-chain fatty acids produced by clostridium bacteria can induce reversible autism-like behavioural and biochemical changes in rats.

“Nicholson’s study did find some biomarkers of gut clostridial populations that we think contribute to autistic symptoms,” says MacFabe, who presented his findings at a meeting of the International Society for Autism Research in Philadelphia, Pennsylvania, last month.

Nicholson emphasises that further research is needed to confirm whether bacteria really are contributing to autism, and if so, how. He also stresses that his findings in no way support claims of a link between vaccines and autism.

Even if bacteria are not actually contributing to the observed metabolic changes, they could still be put to use. “There is probably the basis of a test for autism based on a urinary metabolic profile,” says Nicholson.

Early treatment

Autism is currently diagnosed using a series of behavioural tests, and while children can show symptoms of the condition when as young as 5 months old, a clear diagnosis is not usually possible until they are age 2 or 3 years. This is problematic, because there is growing evidence that the earlier behavioural therapies for autism are started, the better the chances of children being able to lead relatively normal lives.

“If you could identify kids who were at risk much earlier by a chemical test rather than by observing the manifestation of full-blown behaviour, we could get them into therapy much earlier,” says Nicholson.

The next step is to confirm the results in a much larger group of age-matched children, as well as following high-risk children from birth in order to identify whether there are markers that precede the development of autistic symptoms.

About David Drysdale

David Drysdale has worked as an Osteopath in the West End of Glasgow since 1996. David combines a wide range of techniques when treating a patient, ranging from Osteopathic Manipulation, Massage, Trigger Point Therapy, Cranio-Sacral Therapy, Nutrition and Exercise. Treatments are tailored for the Patient. It is understood that some people simply do not like osteopathic manipulation, while others like Deep Tissue Massage, or benefit from Cranio-Sacral Therapy. There are different ways of treating people who are in pain, and providing the treatment that works for you is very important. Osteopathy is well known for treating Headaches, Neck & Back Pain, but many other conditions such as migraines, frozen shoulder and arthritis can all respond well to good Osteopathic treatment.
This entry was posted in Autism, Breast Feeding, Diet, Gut Bacteria, Immune system, Irritable Bowel Syndrome, Nutrition and tagged , , . Bookmark the permalink.

6 Responses to Autism & Gut Bacteria

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